Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diethylene Glycol Monoethyl Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylene Glycol Monoethyl Ether SCHEMBL8014385 | 1.00 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL16399 | 0.97 | — | — | |
| Diethylene Glycol Monoethyl Ether SCHEMBL2743512 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL12595173 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL18418083 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL6123956 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL16318328 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL3268631 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Triethylene Glycol SCHEMBL21647314 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL15659 | 0.97 | ALDH1A1 (0.88) | ALDH1A1MEN1KMT2ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118304279-A | Calcitriol self-microemulsion mouth dissolving film and preparation method thereof | 青岛双鲸药业股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| US-11939550-B2 | Borated detergents and their lubricating applications | INFINEUM INTERNATIONAL LIMITED (GB) | 2024-03-26 | — | — | US | disclosed |
| US-11905488-B2 | Transmission fluid compositions for hybrid and electric vehicle applications | INFINEUM INTERNATIONAL LIMITED (GB) | 2024-02-20 | — | — | US | disclosed |
| US-20240000757-A1 | TOPICAL FORMULATION COMPRISING SIROLIMUS | SODHA PHARMA CONSULTING GMBH (CH) | 2024-01-04 | — | — | US | disclosed |
| EP-4228598-B1 | TOPICAL FORMULATION COMPRISING SIROLIMUS | SODHA PHARMA CONSULTING GMBH (CH) | 2023-12-27 | — | — | EP | disclosed |
| EP-4267708-A1 | THERMALLY RESPONSIVE BRUSH POLYMERS HAVING A COPOLYMER BACKBONE AND COPOLYMER ARMS | Infineum International Limited (GB) | 2023-11-01 | — | — | EP | disclosed |
| EP-4228598-A1 | TOPICAL FORMULATION COMPRISING SIROLIMUS | Sodha Pharma Consulting GmbH (CH) | 2023-08-23 | — | — | EP | disclosed |
| EP-4222237-A1 | REJUVENATION AND/OR EXTENSION OF THE LIFETIME OF FRICTIONAL PERFORMANCE IN TRANSMISSION FLUIDS | Infineum International Limited (GB) | 2023-08-09 | — | — | EP | disclosed |
| US-11685874-B2 | High viscosity index comb polymer viscosity modifiers and methods of modifying lubricant viscosity using same | INFINEUM INTERNATIONAL LIMITED (GB) | 2023-06-27 | — | — | US | disclosed |
| US-20230183593-A1 | BORATED DETERGENTS AND THEIR LUBRICATING APPLICATIONS | INFINEUM INTERNATIONAL LIMITED (GB) | 2023-06-15 | — | — | US | disclosed |
| EP-0545653-A1 | Ashless dispersants formed form substituted acylating agents and their production and use | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0516461-A1 | Lubricating oil compositions and concentrates and the use thereof | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| US-5137980-A | Reacting polyisobutene with aacidic reactant; super atmospheric pressure; low tar rating | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0493928-A1 | Lubricating oil compositions, concentrates and the use thereof | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0492934-A1 | Lubricating oil compositions and concentrates and the use thereof | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-RE33786-E | Oxidation | CLAIROL, INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4776855-A | ALKALINE COMPOUND-POLYMER BLEND THAT THICKENS UPON APPLYING | CLAIROL INC. (US) | 1988-10-11 | — | — | US | disclosed |
| US-4506048-A | POLYACRYLATES | THE PROCTER & GAMBLE COMPANY (US) | 1985-03-19 | — | — | US | disclosed |
| US-4483967-A | COBALT COMPOUNDS AND DIOXOLANE COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 1984-11-20 | — | — | US | disclosed |
| US-4395361-A | A 1,3-DIOXOLANE AUTOAXIDIZABLE TO A PEROXIDE AND A TRANSITION METAL COMPOUND CATALYST; CROSSLINKING PAINTS | THE PROCTER & GAMBLE COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240000757-A1 | TOPICAL FORMULATION COMPRISING SIROLIMUS | RICTOR, MTOR, MLST8 | ALDH1A1 4548/4885MEN1 391/4885KMT2A 2243/4885 |
| US-11939550-B2 | Borated detergents and their lubricating applications | TBK1, BRSK1, CA6 | ALDH1A1 2741/4885MEN1 2618/4885KMT2A 2801/4885 |
| US-20230183593-A1 | BORATED DETERGENTS AND THEIR LUBRICATING APPLICATIONS | TBK1, BRSK1, CA6 | ALDH1A1 2741/4885MEN1 2618/4885KMT2A 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.