Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | ARG1 | P05089 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817184 | 1.00 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| Bromide SCHEMBL11268278 | 0.98 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL1819135 | 0.86 | HRH3 (0.56) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL11234764 | 0.86 | HRH3 (0.56) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL10956783 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL414249 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL440476 | 0.86 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL11242292 | 0.85 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL4849081 | 0.85 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HRH3ARG1 | |
| SCHEMBL1818182 | 0.85 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HRH3ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113967258-B | FAP-activated therapeutic agents and related uses | 塔夫茨大学信托人 | 2024-07-02 | — | — | CN | disclosed |
| EP-0049589-A1 | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
| US-4311705-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |