Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.55 |
| ▸ | PPARG | P37231 | 4/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KLK7 | P49862 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227027 | 0.86 | PPARA (0.57) | PPARAPPARGCHRNB2CHRNA4MAPT | |
| SCHEMBL27585390 | 0.86 | LMNA (0.51) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14945154 | 0.86 | LMNA (0.51) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL11244292 | 0.80 | PPARG (0.59) | PPARAPPARGCHRNB2CHRNA4MAPT | |
| SCHEMBL16672673 | 0.78 | MMP8 (0.54) | MEN1KMT2AALDH1A1LMNATDP1 | |
| SCHEMBL27652260 | 0.78 | MMP8 (0.54) | MEN1KMT2AALDH1A1LMNATDP1 | |
| SCHEMBL17653672 | 0.78 | MMP8 (0.54) | MEN1KMT2AALDH1A1LMNATDP1 | |
| SCHEMBL1966776 | 0.76 | LMNA (0.55) | PPARAPPARGMAPTLMNACYP1A2 | |
| SCHEMBL9291604 | 0.76 | SLC6A2 (0.50) | PPARAPPARGCHRNB2CHRNA4MEN1 | |
| SCHEMBL17724583 | 0.76 | ALDH1A1 (0.51) | PPARAPPARGMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009306-B1 | ANTI-ARTHRITIC HYDROXYACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-24 | — | — | EP | disclosed |
| US-4310544-A | Hydroxyacetic acid derivatives with anti-arthritic properties | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-01-12 | — | — | US | disclosed |
| EP-0009306-A1 | Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |