Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239858 | 0.93 | HMOX1 (0.40) | KCNH2HMOX1CYP2C9LMNAGRM6 | |
| SCHEMBL11252422 | 0.89 | HMOX1 (0.41) | KCNH2HMOX1CYP2C9LMNAGRM6 | |
| SCHEMBL11245098 | 0.86 | CYP2C9 (0.44) | KCNH2HMOX1CYP2C9LMNAGRM6 | |
| SCHEMBL11244932 | 0.86 | HMOX1 (0.48) | HMOX1 | |
| SCHEMBL11239102 | 0.85 | HMOX1 (0.47) | HMOX1CYP19A1 | |
| SCHEMBL11241392 | 0.84 | CYP2C9 (0.43) | KCNH2HMOX1CYP2C9LMNAGRM6 | |
| SCHEMBL11235289 | 0.83 | POLB (0.40) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11246480 | 0.80 | HMOX1 (0.61) | HMOX1LMNAUSP2ALDH1A1ALOX15 | |
| SCHEMBL11235305 | 0.79 | CYP19A1 (0.42) | HMOX1CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11242344 | 0.79 | HMOX1 (0.49) | HMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |