Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.63 |
| ▸ | UBE2N | P61088 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 4/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250564 | 0.86 | ALDH1A1 (0.56) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11242205 | 0.86 | CASP1 (0.57) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11240559 | 0.85 | ALDH1A1 (0.55) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL7720232 | 0.85 | MAPT (0.54) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11235489 | 0.84 | CASP1 (0.55) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11233626 | 0.83 | ALDH1A1 (0.53) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL7276252 | 0.83 | HPGD (0.57) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11244496 | 0.83 | ALDH1A1 (0.53) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11233605 | 0.83 | ALDH1A1 (0.53) | ALDH1A1MAPK1HPGDCLK1UBE2N | |
| SCHEMBL11230793 | 0.82 | CASP1 (0.53) | ALDH1A1MAPK1HPGDCLK1UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |