Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | UBE2N | P61088 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723102 | 0.87 | PLA2G2A (0.54) | MAPTL3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL7724769 | 0.86 | MAPT (0.55) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL7723543 | 0.85 | MAPT (0.57) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL11236330 | 0.85 | ALDH1A1 (0.63) | MAPTALDH1A1HPGDKDM4EUBE2N | |
| SCHEMBL7720367 | 0.85 | MAPT (0.51) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL7723506 | 0.84 | MAPT (0.55) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL7724805 | 0.84 | MAPT (0.50) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL4692400 | 0.84 | MAPT (0.66) | MAPTPOLBTDP1L3MBTL1APEX1 | |
| SCHEMBL7276252 | 0.83 | HPGD (0.57) | MAPTTDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL7724761 | 0.83 | MAPT (0.54) | MAPTPOLBTDP1L3MBTL1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |