Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245877 | 0.86 | GSK3B (0.45) | PIK3CBGSK3BSPRMAPK1TLR8 | |
| SCHEMBL11225759 | 0.86 | GSK3B (0.43) | PIK3CBGSK3BMAP4K4CLK1DYRK1A | |
| SCHEMBL11244896 | 0.85 | GSK3B (0.49) | GSK3BMAP4K4SPRMAPK1IKBKE | |
| SCHEMBL11233480 | 0.80 | GSK3B (0.52) | GSK3BDYRK1AMAPK1CYP11B2EGFR | |
| SCHEMBL11237181 | 0.79 | GSK3B (0.46) | GSK3BSPRMAPK1KDR | |
| SCHEMBL11386279 | 0.75 | PIK3CB (0.43) | PIK3CBMAP4K4CLK1DYRK1AMAPK1 | |
| SCHEMBL11229632 | 0.75 | GSK3B (0.52) | GSK3BMAP4K4MAPK1 | |
| SCHEMBL11236377 | 0.74 | GSK3B (0.48) | PIK3CBGSK3BMAP4K4MAPK1IKBKE | |
| SCHEMBL11236404 | 0.74 | GSK3B (0.42) | GSK3BSPRMAPK1TLR7CYP11B2 | |
| SCHEMBL11234436 | 0.73 | GSK3B (0.50) | GSK3BMAP4K4MAPK1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |