Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11526442 | 0.86 | DNM1 (0.62) | TSHRDNM1BDKRB2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11103790 | 0.82 | TSHR (0.48) | TSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL5145658 | 0.80 | TSHR (0.50) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL3361978 | 0.79 | TSHR (0.46) | TSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL23198627 | 0.79 | DNM1 (0.75) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL124627 | 0.79 | DNM1 (0.75) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| Thiocyanic Acid SCHEMBL31021419 | 0.77 | DNM1 (0.57) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| Cyanate SCHEMBL10909220 | 0.77 | DNM1 (0.57) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| SCHEMBL31447339 | 0.77 | TSHR (0.52) | TSHRDNM1BDKRB2ALDH1A1TDP1 | |
| Acetonitrile SCHEMBL28136456 | 0.77 | DNM1 (0.62) | TSHRDNM1BDKRB2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4335051-A | AQUEOUS ALKALI HYDROXIDE AS ACID ACCEPTOR WHEN REACTING METHANOL W | BAYER AKTIENGESELLSCHAFT (DE) | 1982-06-15 | — | — | US | disclosed |