Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.49 |
| ▸ | WNT3A | P56704 | 5/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11321191 | 0.85 | AVPR1A (0.56) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11223398 | 0.85 | ADAM17 (0.57) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11312535 | 0.83 | AVPR1A (0.56) | ALDH1A1ADAM17CTNNB1WNT3ACCR2 | |
| SCHEMBL11233886 | 0.82 | ALDH1A1 (0.66) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL11314928 | 0.81 | KMT2A (0.50) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11311849 | 0.81 | ADAM17 (0.50) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11311419 | 0.81 | ADAM17 (0.50) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11221666 | 0.81 | KDM1A (0.54) | ALDH1A1ADAM17KDM4EBRD4POLB | |
| SCHEMBL11223947 | 0.78 | AVPR1A (0.62) | ADAM17 | |
| SCHEMBL11311808 | 0.77 | ADAM17 (0.47) | ALDH1A1ADAM17POLBCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |