Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.56 |
| ▸ | WNT3A | P56704 | 5/20 | 0.56 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11321191 | 0.91 | AVPR1A (0.56) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11311419 | 0.91 | ADAM17 (0.50) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11314928 | 0.91 | KMT2A (0.50) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11221666 | 0.91 | KDM1A (0.54) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11311849 | 0.91 | ADAM17 (0.50) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11312535 | 0.89 | AVPR1A (0.56) | ADAM17CTNNB1WNT3AAVPR1AESR1 | |
| SCHEMBL11223947 | 0.87 | AVPR1A (0.62) | ADAM17AVPR1ADRD2DRD4DRD3 | |
| SCHEMBL11251234 | 0.87 | AVPR1A (0.49) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11229177 | 0.87 | TPSAB1 (0.56) | ADAM17CTNNB1WNT3AAVPR1ADRD2 | |
| SCHEMBL11247565 | 0.87 | ALDH1A1 (0.51) | AVPR1ADRD2DRD4DRD3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |