Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246002 | 0.87 | CYP11B1 (0.57) | CYP11B1CYP11B2ALDH1A1HMOX2 | |
| SCHEMBL11244892 | 0.87 | CYP11B1 (0.60) | CYP11B1CYP11B2TBXAS1HMOX2CYP19A1 | |
| SCHEMBL8804091 | 0.86 | CYP19A1 (0.56) | CYP11B1CYP11B2TBXAS1HMOX2PLA2G4A | |
| SCHEMBL11237322 | 0.85 | CYP11B1 (0.59) | CYP11B1CYP11B2ALDH1A1HMOX2CYP19A1 | |
| Hydrochloric Acid SCHEMBL408146 | 0.84 | TBXAS1 (0.57) | CYP11B1CYP11B2TBXAS1HMOX2PLA2G4A | |
| SCHEMBL8802725 | 0.83 | WDR5 (0.49) | CYP11B1CYP11B2ALDH1A1TBXAS1HMOX2 | |
| SCHEMBL11247258 | 0.81 | TBXAS1 (0.44) | CYP11B1CYP11B2ALDH1A1TBXAS1HMOX2 | |
| SCHEMBL11269558 | 0.80 | PLA2G4A (0.58) | ALDH1A1TBXAS1HMOX2PLA2G4A | |
| SCHEMBL8803778 | 0.80 | TBXAS1 (0.56) | ALDH1A1TBXAS1HMOX2PLA2G4A | |
| SCHEMBL11238995 | 0.79 | CYP11B1 (0.54) | CYP11B1CYP11B2ALDH1A1TBXAS1HMOX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |