Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PTGES | O14684 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11711628 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNANPSR1TDP1 | |
| SCHEMBL11245322 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNANPSR1TDP1 | |
| SCHEMBL11231697 | 0.84 | KDM4E (0.39) | ALDH1A1KDM4ELMNANPSR1TDP1 | |
| SCHEMBL11469872 | 0.84 | CACNA2D1 (0.48) | ALDH1A1KDM4ELMNANPSR1PTGES | |
| SCHEMBL11239685 | 0.84 | PTGES (0.50) | ALDH1A1KDM4ELMNANPSR1TDP1 | |
| SCHEMBL11714188 | 0.83 | ADORA2A (0.47) | ALDH1A1KDM4ENPSR1TDP1KMT2A | |
| SCHEMBL11338853 | 0.83 | ADORA1 (0.47) | ALDH1A1KDM4ELMNANPSR1L3MBTL1 | |
| SCHEMBL11268851 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1KDM4ELMNANPSR1TDP1 | |
| SCHEMBL11475908 | 0.82 | RAB9A (0.47) | ALDH1A1KDM4EL3MBTL1PTGESKMT2A | |
| SCHEMBL11485833 | 0.82 | PTGES (0.51) | ALDH1A1KDM4ELMNANPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4318911-A | 5,6-Diaryl-1,2,4-triazines as topical antithrombotic agents | ELI LILLY AND COMPANY (US) | 1982-03-09 | — | — | US | claimed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | claimed |
| US-4318911-A | 5,6-Diaryl-1,2,4-triazines as topical antithrombotic agents | ELI LILLY AND COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |