Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105179 | 0.92 | CYP2C9 (0.57) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12201990 | 0.89 | NOTUM (0.60) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL1105181 | 0.83 | NOTUM (0.65) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12202001 | 0.81 | NOTUM (0.61) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12201987 | 0.80 | NOTUM (0.65) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12201981 | 0.80 | NOTUM (0.65) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12201982 | 0.76 | NOTUM (0.58) | NOTUMCYP2C9MEN1KMT2APOLB | |
| SCHEMBL12201988 | 0.75 | NOTUM (0.66) | NOTUMMEN1KMT2APOLBNPC1 | |
| SCHEMBL12201992 | 0.75 | NOTUM (0.59) | NOTUMCYP2C9POLBMAPTCYP1A2 | |
| SCHEMBL12201989 | 0.73 | NOTUM (0.58) | NOTUMPOLBNPC1NOD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153654-B2 | — | — | 2012-04-10 | — | — | US | disclosed |
| US-20090186917-A1 | 6-And 7-amino isoquinoline compounds and methods for making and using the same | AERIE PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186917-A1 | 6-And 7-amino isoquinoline compounds and methods for making and using the same | COQ8A, MAP3K7, PRKG2 | NOTUM 2328/4885CYP2C9 1318/4885MEN1 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.