Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.68 |
| ▸ | HTT | P42858 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | BRD4 | O60885 | 5/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114710 | 0.81 | KDM4E (0.74) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL30159468 | 0.81 | KDM4E (1.00) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL9177673 | 0.81 | KDM4E (0.79) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL31237495 | 0.81 | KDM4E (0.79) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL1782934 | 0.81 | KDM4E (1.00) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL17018636 | 0.80 | BRD4 (0.78) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL4564667 | 0.80 | KDM4E (0.96) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL1317977 | 0.80 | KDM4E (0.77) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL27906143 | 0.80 | KDM4E (0.96) | KDM4EL3MBTL1HTTNPC1LMNA | |
| SCHEMBL10157041 | 0.79 | KDM4E (0.70) | KDM4EL3MBTL1HTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-03-08 | — | — | US | disclosed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FECH, HMOX1, FTH1 | KDM4E 3494/4885L3MBTL1 908/4885HTT 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.