Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 2/20 | 0.54 |
| ▸ | CA6 | P23280 | 2/20 | 0.54 |
| ▸ | CA5A | P35218 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | POU5F1 | Q01860 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | SLC47A2 | Q86VL8 | 2/20 | 0.54 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.54 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11385711 | 0.86 | HRH2 (0.56) | HRH2SLC22A2CA12SLC22A3CA1 | |
| SCHEMBL11246474 | 0.85 | HRH2 (0.60) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Maleic Acid SCHEMBL11387637 | 0.84 | HRH2 (0.53) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Hydrochloric Acid SCHEMBL11249059 | 0.84 | HRH2 (0.59) | HRH2SLC22A2CA12SLC22A3CA1 | |
| SCHEMBL18335720 | 0.80 | HRH2 (0.68) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL27832811 | 0.80 | HRH2 (0.86) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL188452 | 0.79 | HRH2 (0.67) | HRH2SLC22A2CA12SLC22A3CA1 | |
| SCHEMBL16386284 | 0.79 | HRH2 (0.66) | HRH2SLC22A2CA12SLC22A3CA1 | |
| SCHEMBL9817418 | 0.79 | HRH2 (0.70) | HRH2SLC22A2CA12SLC22A3CA1 | |
| SCHEMBL11380937 | 0.78 | HRH2 (0.63) | HRH2SLC22A2CA12SLC22A3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362736-A | ANTISECRETORY AGENTS, GASTRIC JUICE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1982-12-07 | — | — | US | disclosed |