SCHEMBL11380937

SCHEMBL11380937

CS(=O)(=O)NC(=N)CCSCc1csc(N=C(N)N)n1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 3/20 0.63
SLC22A2 O15244 2/20 0.63
CA12 O43570 2/20 0.63
SLC22A3 O75751 2/20 0.63
CA1 P00915 2/20 0.63
CA2 P00918 2/20 0.63
LMNA P02545 2/20 0.63
TSHR P16473 2/20 0.63
MAOA P21397 2/20 0.63
CA4 P22748 2/20 0.63
CA6 P23280 2/20 0.63
CA5A P35218 2/20 0.63
CA7 P43166 2/20 0.63
BLM P54132 2/20 0.63
PMP22 Q01453 2/20 0.63
POU5F1 Q01860 2/20 0.63
CA9 Q16790 2/20 0.63
SLC47A2 Q86VL8 2/20 0.63
CA13 Q8N1Q1 2/20 0.63
SLC47A1 Q96FL8 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL11385711 0.93 HRH2 (0.56) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL188452 0.90 HRH2 (0.67) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11382761 0.89 HRH2 (0.60) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11393006 0.87 HRH2 (0.58) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11389410 0.84 HRH2 (0.62) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11246474 0.83 HRH2 (0.60) HRH2SLC22A2CA12SLC22A3CA1
Hydrochloric Acid SCHEMBL11249059 0.82 HRH2 (0.59) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11378486 0.81 CA2 (0.54) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL11380940 0.81 HRH2 (0.40) HRH2SLC22A2CA12SLC22A3CA1
SCHEMBL16386284 0.81 HRH2 (0.66) HRH2SLC22A2CA12SLC22A3CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4283408-A Guanidinothiazole compounds, process for preparation and gastric inhibiting compositions containing them YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1981-08-11 US claimed
WO-2021183259-A1 FAMOTIDINE AND FAMOTIDINE ANALOGS FOR CORONA VIRUS TREATMENT Nanopharmaceutics, Inc. (US) 2021-09-16 WO disclosed
US-20140220057-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC. (JP) 2014-08-07 US disclosed
US-20140220055-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC. (JP) 2014-08-07 US disclosed
US-20140220079-A1 VACCINE COMPOSITION FOR MUCOSAL ADMINISTRATION NITTO DENKO CORPORATION (JP) 2014-08-07 US disclosed
US-20140220059-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR MUCOSAL ADMINISTRATION INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC. (JP) 2014-08-07 US disclosed
US-20140220105-A1 TAPE PREPARATION OF WT1 PEPTIDE CANCER VACCINE FOR TRANSDERMAL ADMINISTRATION INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC. (JP) 2014-08-07 US disclosed
US-4283408-A Guanidinothiazole compounds, process for preparation and gastric inhibiting compositions containing them YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1981-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140220105-A1 TAPE PREPARATION OF WT1 PEPTIDE CANCER VACCINE FOR TRANSDERMAL ADMINISTRATION TAP1, TAP2, MICA HRH2 4573/4885SLC22A2 1951/4885CA12 574/4885
US-20140220057-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION TAP1, TAP2, MUC1 HRH2 3391/4885SLC22A2 422/4885CA12 121/4885
US-20140220055-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION TAP1, TAP2, MICA HRH2 3944/4885SLC22A2 898/4885CA12 256/4885
US-20140220079-A1 VACCINE COMPOSITION FOR MUCOSAL ADMINISTRATION MUC1, ERBB2, TLR5 HRH2 178/4885SLC22A2 2174/4885CA12 165/4885
US-20140220059-A1 WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR MUCOSAL ADMINISTRATION MUC1, TAP1, MICA HRH2 3453/4885SLC22A2 1026/4885CA12 143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.