Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11225309 | 0.87 | NR1D1 (0.39) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11237364 | 0.85 | NR1D1 (0.38) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11229155 | 0.84 | GSK3B (0.47) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11234298 | 0.84 | ROCK2 (0.42) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11238837 | 0.78 | DYRK1A (0.36) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11232476 | 0.78 | GSK3B (0.49) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11231428 | 0.77 | NR1D1 (0.39) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11229298 | 0.74 | LATS1 (0.40) | NR1D1PDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11252715 | 0.73 | LATS1 (0.36) | NR1D1CYP3A4KDM4EALDH1A1MAPT | |
| SCHEMBL11226000 | 0.72 | GSK3B (0.49) | PDGFRBPDGFRACYP3A4KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |