Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 7/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237850 | 0.87 | PRMT5 (0.43) | HCAR2ALPLPRMT5WDR77CYP11B2 | |
| SCHEMBL11233232 | 0.84 | PRMT5 (0.44) | PRMT5WDR77CYP11B2CYP11B1CDK7 | |
| SCHEMBL11248675 | 0.83 | MAPT (0.45) | ALPLPRMT5WDR77KDM4EGAA | |
| SCHEMBL20471668 | 0.81 | ALPL (0.65) | ALPLCA9KDM4ELMNAMAPT | |
| SCHEMBL4853168 | 0.78 | ALDH1A1 (0.58) | HCAR2KDM4EGAAALKTP53 | |
| SCHEMBL11242185 | 0.78 | ALPL (0.42) | HCAR2ALPLCA9KDM4EGAA | |
| SCHEMBL11245554 | 0.78 | PRMT5 (0.47) | PRMT5WDR77CYP11B2CYP11B1ALK | |
| SCHEMBL21001258 | 0.77 | ALPL (0.46) | ALPLPRMT5WDR77CA9TP53 | |
| SCHEMBL4849085 | 0.77 | ALPL (0.46) | HCAR2ALPLCA9KDM4EGAA | |
| SCHEMBL2950654 | 0.76 | GSK3B (0.53) | ALPLCA9GAATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |