Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14910773 | 0.83 | CYP11B2 (0.42) | PRMT5WDR77CYP11B2ALKCYP11B1 | |
| SCHEMBL11237850 | 0.80 | PRMT5 (0.43) | PRMT5WDR77CYP11B2ALKCYP11B1 | |
| SCHEMBL11239129 | 0.78 | HCAR2 (0.42) | PRMT5WDR77CYP11B2ALKCYP11B1 | |
| SCHEMBL11233232 | 0.76 | PRMT5 (0.44) | PRMT5WDR77CYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL11245286 | 0.76 | CYP1A2 (0.63) | PRMT5WDR77PDE3BPDE3APDE2A | |
| SCHEMBL11231763 | 0.76 | PDE3B (0.46) | PRMT5WDR77PDE3BPDE3APDE2A | |
| SCHEMBL4055335 | 0.74 | LMNA (0.62) | PRMT5WDR77PDE3BPDE3ACYP11B2 | |
| SCHEMBL11242864 | 0.73 | PDE3B (0.61) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL11449641 | 0.73 | AURKB (0.66) | PRMT5WDR77PDE3BPDE3ACYP11B2 | |
| SCHEMBL11248675 | 0.73 | MAPT (0.45) | PRMT5WDR77ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |