Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240299 | 0.88 | RYR2 (0.35) | HSD17B10TDP1MEN1KMT2ACYP2C9 | |
| Hydrochloric Acid SCHEMBL11341479 | 0.77 | PTGS2 (0.33) | HSD17B10SLC6A4KDM4EALDH1A1PTGS2 | |
| SCHEMBL27765463 | 0.76 | PTGS2 (0.39) | HSD17B10SLC6A4KDM4EALDH1A1PTGS2 | |
| SCHEMBL25668368 | 0.75 | KDM4E (0.47) | HSD17B10TDP1KMT2ASLC6A4KDM4E | |
| SCHEMBL9480840 | 0.73 | KMT2A (0.51) | HSD17B10TDP1MEN1KMT2ACYP2C9 | |
| SCHEMBL11232725 | 0.73 | CPT1B (0.39) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5328200 | 0.72 | MEN1 (0.50) | HSD17B10TDP1MEN1KMT2ACYP2C9 | |
| SCHEMBL11456831 | 0.72 | TDP1 (0.50) | HSD17B10TDP1MEN1KMT2ACYP2C9 | |
| SCHEMBL25668374 | 0.72 | SLC6A4 (0.31) | HSD17B10TDP1KMT2ASLC6A4KDM4E | |
| SCHEMBL25668370 | 0.72 | VHL (0.31) | SLC6A4VHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341792-A | ANTIDIABETIC AND CARDIOTONIC AGENTS | PFIZER INC. (US) | 1982-07-27 | — | — | US | disclosed |
| EP-0026593-A1 | Bicyclic keto- and amino- acids, esters and amides and pharmaceutical compositions thereof | Pfizer Limited (GB) | 1981-04-08 | — | — | EP | disclosed |