Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | ELOC | Q15369 | 1/20 | 0.32 |
| ▸ | ELOB | Q15370 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527473 | 0.81 | LMNA (0.35) | PTGS1RYR2SLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL27064478 | 0.78 | SLC6A4 (0.33) | RYR2SLC6A4VHLELOCELOB | |
| SCHEMBL25668368 | 0.76 | KDM4E (0.47) | SLC6A4KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL11240299 | 0.76 | RYR2 (0.35) | RYR2SLC6A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11239155 | 0.76 | HSD17B10 (0.46) | PTGS2OPRK1PDE4DRYR2SLC6A4 | |
| SCHEMBL17772914 | 0.75 | ALDH1A1 (0.40) | RYR2SLC6A4ALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL11341479 | 0.75 | PTGS2 (0.33) | PTGS2OPRK1PDE4DRYR2SLC6A4 | |
| SCHEMBL25569526 | 0.74 | ALOX15 (0.44) | SLC6A4KDM4EALDH1A1ALOX15CASP1 | |
| Hydrochloric Acid SCHEMBL11235761 | 0.74 | RYR2 (0.36) | RYR2SLC6A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL25668370 | 0.73 | VHL (0.31) | SLC6A4VHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541756-A | Pyrazoles as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |