Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252898 | 0.83 | HTR7 (0.55) | HTR7ESR1PARP1MAPK1ALDH1A1 | |
| SCHEMBL11223500 | 0.79 | TPSAB1 (0.57) | KMT2AHTR7ESR1PARP1SIGMAR1 | |
| SCHEMBL11239836 | 0.78 | ESR1 (0.56) | KMT2AESR1PARP1ALDH1A1HPGD | |
| SCHEMBL11311675 | 0.76 | TP53 (0.53) | KMT2AMEN1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4198757 | 0.76 | NAMPT (0.65) | HTR7ESR1PARP1SIGMAR1MAPK1 | |
| SCHEMBL11498279 | 0.75 | TPSAB1 (0.55) | KMT2APARP1MAPK1ALDH1A1NAMPT | |
| SCHEMBL11239643 | 0.75 | ESR1 (0.57) | ESR1PARP1ADAMTS5 | |
| SCHEMBL11351356 | 0.74 | ESR1 (0.54) | ESR1PARP1ALDH1A1ADAMTS5NAMPT | |
| SCHEMBL6245254 | 0.74 | NAMPT (0.64) | HTR7ESR1PARP1SIGMAR1MAPK1 | |
| SCHEMBL11240652 | 0.74 | TPSAB1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |