SCHEMBL11240104

SCHEMBL11240104

CS(=O)(=O)OC(c1cccnc1)C(Cl)(Cl)Cl

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.42
CYP3A5 P20815 3/20 0.42
CYP19A1 P11511 1/20 0.41
CFTR P13569 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
GOPC Q9HD26 1/20 0.39
LMNA P02545 2/20 0.38
MAPK1 P28482 1/20 0.38
GAA P10253 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11253783 0.82 CYP3A4 (0.44) CYP3A4CYP3A5CYP19A1CFTRSLC6A2
Acetic Acid SCHEMBL27871968 0.79 LMNA (0.42) CFTRSLC6A2SLC6A4SLC6A3GOPC
SCHEMBL18326357 0.78 CYP19A1 (0.45) CYP3A4CYP3A5CYP19A1CFTRSLC6A2
SCHEMBL11228700 0.76 ALDH1A1 (0.45) CYP3A4CYP3A5CYP19A1LMNAMAPK1
SCHEMBL12281743 0.73 CFTR (0.39) CYP3A4CYP3A5CFTRSLC6A2SLC6A4
SCHEMBL19716861 0.73 LMNA (0.46) CYP19A1CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL11241260 0.72 LMNA (0.43) CYP19A1LMNAGAASMN1; SMN2L3MBTL1
SCHEMBL11244521 0.72 POLB (0.39) CYP3A4CYP3A5CYP19A1GAA
SCHEMBL9844918 0.72 KCNA5 (0.47) CYP3A4LMNA
SCHEMBL11236544 0.71 KCNA5 (0.43) CYP19A1LMNASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4339455-A 1-(3-Pyridyl)-2,2,2-trihaloethyl compounds and fungicidal compositions containing the same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1982-07-13 US claimed
US-4339455-A 1-(3-Pyridyl)-2,2,2-trihaloethyl compounds and fungicidal compositions containing the same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1982-07-13 US disclosed
US-4189486-A FUNGICIDES CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1980-02-19 US disclosed