SCHEMBL11240306

SCHEMBL11240306

N#Cc1cccc(CCl)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.41
P2RX7 Q99572 5/20 0.38
TSHR P16473 2/20 0.35
CYP19A1 P11511 1/20 0.35
PNMT P11086 1/20 0.34
DYRK1A Q13627 1/20 0.34
ALDH1A1 P00352 2/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
AR P10275 1/20 0.33
NPBWR1 P48145 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15129482 0.83 PNMT (0.54) XDHP2RX7TSHRCYP19A1PNMT
SCHEMBL16960269 0.82 XDH (0.40) XDHP2RX7TSHRCYP19A1PNMT
SCHEMBL16953236 0.82 XDH (0.43) XDHP2RX7TSHRCYP19A1DYRK1A
SCHEMBL8878530 0.82 XDH (0.40) XDHP2RX7TSHRCYP19A1PNMT
SCHEMBL7103488 0.82 XDH (0.43) XDHP2RX7TSHRHTR2AHTR2C
SCHEMBL1434373 0.80 CYP19A1 (0.46) TSHRCYP19A1ALDH1A1MAPTSMN1; SMN2
SCHEMBL3237062 0.79 TSHR (0.46) TSHRDYRK1AALDH1A1HTR2AHTR2C
SCHEMBL27756124 0.79 SMN1; SMN2 (0.37) P2RX7TSHRCYP19A1ALDH1A1MAPT
SCHEMBL16957570 0.79 XDH (0.41) XDHP2RX7TSHRCYP19A1PNMT
SCHEMBL10798754 0.78 PLAU (0.36) TSHRCYP19A1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4331821-A ULTRAVIOLET RADIATION OF A VAPORIZED ALKYLBENZEN AND HALOGEN GAS MIXTURE BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed