Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.43 |
| ▸ | QPCT | Q16769 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242901 | 0.93 | QPCT (0.46) | TP53KDM4ETSHRCYP2A6CYP19A1 | |
| SCHEMBL11244112 | 0.92 | TP53 (0.47) | TP53KDM4ETSHRCYP2A6CYP19A1 | |
| SCHEMBL11246654 | 0.89 | QPCT (0.44) | TP53KDM4ETSHRCYP19A1CYP11B1 | |
| SCHEMBL11253540 | 0.88 | TBXAS1 (0.45) | CYP19A1CYP11B1CYP11B2HMOX1QPCT | |
| SCHEMBL11231289 | 0.87 | TP53 (0.48) | TP53KDM4ETSHRCYP2A6CYP19A1 | |
| Hydrochloric Acid SCHEMBL11240259 | 0.86 | TP53 (0.47) | TP53KDM4ETSHRCYP2A6CYP19A1 | |
| SCHEMBL11236382 | 0.86 | KMT2A (0.47) | TP53KDM4ECYP11B1CYP11B2HMOX1 | |
| SCHEMBL11233770 | 0.86 | MEN1 (0.49) | TP53KDM4ETSHRCYP19A1QPCT | |
| SCHEMBL11244362 | 0.85 | QPCT (0.47) | TP53KDM4ETSHRCYP2A6CYP19A1 | |
| SCHEMBL10851164 | 0.84 | HMOX1 (0.45) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |