Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255092 | 0.92 | HTT (0.52) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL11245716 | 0.91 | HTT (0.55) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL9208885 | 0.91 | HTT (0.55) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL8961445 | 0.90 | TSHR (0.57) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL8961486 | 0.89 | LMNA (0.51) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL9851181 | 0.89 | KMT2A (0.58) | TSHRKMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL11384074 | 0.86 | HTT (0.50) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL11553497 | 0.86 | HTT (0.50) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL20618032 | 0.86 | LMNA (0.51) | HTTTSHRKMT2ANQO2LMNA | |
| SCHEMBL11559597 | 0.86 | ADRA1D (0.56) | HTTTSHRKMT2AALDH1A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4324787-A | 2-Oxo-1-pyrrolidineacetic acid compounds and their medicinal use | TROPONWERKE GMBH & CO., KG (DE) | 1982-04-13 | — | — | US | disclosed |
| EP-0003029-B1 | NEW 2-OXO-1-PYRROLIDINE ACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | Troponwerke GmbH & Co. KG (DE) | 1980-12-10 | — | — | EP | disclosed |