Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245569 | 0.90 | CASP1 (0.46) | CASP1CDC7MAPTALDH1A1HPGD | |
| SCHEMBL11238940 | 0.89 | KDM4C (0.42) | CNR1CNR2MAPTALDH1A1HPGD | |
| SCHEMBL11231677 | 0.89 | CNR1 (0.43) | CNR1CNR2MAPTSMPD1 | |
| SCHEMBL11242717 | 0.88 | CASP1 (0.44) | CASP1CDC7MAPTALDH1A1HPGD | |
| SCHEMBL11245678 | 0.87 | CASP1 (0.45) | CASP1CDC7MAPTALDH1A1HPGD | |
| SCHEMBL11244496 | 0.85 | ALDH1A1 (0.53) | CASP1CDC7MAPTALDH1A1HPGD | |
| SCHEMBL11237167 | 0.85 | CASP1 (0.48) | CASP1CDC7MAPTALDH1A1HPGD | |
| SCHEMBL11246951 | 0.84 | CASP1 (0.47) | CASP1CDC7MAPTCCNCCDK8 | |
| SCHEMBL11238873 | 0.83 | AURKA (0.45) | CNR1CNR2TLR8MAPTALDH1A1 | |
| SCHEMBL11248872 | 0.80 | CASP1 (0.45) | CASP1CDC7MAPTCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |