Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11253598 | 0.92 | KDM4E (0.42) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL3454088 | 0.83 | KDM4E (0.61) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL11466444 | 0.76 | KDM4E (0.62) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL11252736 | 0.74 | KDM4E (0.46) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL8810668 | 0.74 | LMNA (0.56) | ALDH1A1HPGDGAATP53TSHR | |
| SCHEMBL13764664 | 0.72 | MAPT (0.52) | KMT2AHTR1AHTR2AHTR2CALDH1A1 | |
| SCHEMBL24376184 | 0.71 | KDM4E (0.53) | KDM4EALDH1A1LMNA | |
| SCHEMBL13483289 | 0.71 | ALDH1A1 (0.69) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL2921304 | 0.69 | ALDH1A1 (0.60) | HTR2AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL11248049 | 0.69 | KDM4E (0.39) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004389-B1 | 4-AMINO-6,7-DIMETHOXY QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND A PHARMACEUTICAL COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-07 | — | — | EP | claimed |
| EP-0004389-B1 | 4-AMINO-6,7-DIMETHOXY QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND A PHARMACEUTICAL COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-04-07 | — | — | EP | disclosed |