Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11821997 | 0.99 | MAPT (0.64) | MAPTADRB2ADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11085988 | 0.99 | MAPT (0.64) | MAPTADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL11242977 | 0.85 | MAPT (0.57) | MAPTADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL11870445 | 0.84 | MAPT (0.78) | MAPTADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL11234902 | 0.83 | ADRB2 (0.55) | MAPTADRB2ADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11870616 | 0.82 | MAPT (0.81) | MAPTADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL11331710 | 0.82 | ADRB2 (0.63) | ADRB2ADRB1HTR1AADRA2AHTR2B | |
| SCHEMBL11824244 | 0.81 | L3MBTL1 (0.62) | MAPTADRB2ADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11824701 | 0.81 | ADRB2 (0.64) | ADRB2ADRB1HTR1AADRA2AHTR2B | |
| SCHEMBL11352373 | 0.81 | ACHE (0.61) | MAPTADRB2ADRB1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4310527-A | DISORDERS OF CAROIAC RHYTHM AND CORONARY HEART DISEASES AND HYDPERTENSION | CIBA-GEIGY CORPORATION (US) | 1982-01-12 | — | — | US | disclosed |
| EP-0003298-B1 | 4-HYDROXY-2-BENZIMIDAZOLIN-THION DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-03-25 | — | — | EP | disclosed |
| US-4140789-A | ADRENERGIC BLOCKING AGENTS, CARDIOTONIC, ANTIARRHYTHMIA, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |