Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241124 | 0.77 | ROCK2 (0.43) | CYP3A4TDP1 | |
| SCHEMBL11240092 | 0.75 | TSHR (0.39) | ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL17875696 | 0.69 | BRD4 (0.44) | ALDH1A1CYP3A4TSHR | |
| SCHEMBL29745144 | 0.68 | ATR (0.37) | — | |
| SCHEMBL30873896 | 0.68 | SMN1; SMN2 (0.44) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL23123144 | 0.68 | ATR (0.37) | — | |
| SCHEMBL11238222 | 0.67 | ADORA2A (0.41) | ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL11226155 | 0.66 | SIRT2 (0.47) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL1326003 | 0.66 | ALDH1A1 (0.39) | ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL11228950 | 0.65 | MAP2K3 (0.58) | ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |