Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 3/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11225157 | 0.79 | CCNC (0.39) | MAP4K1CCNCCDK8CYP1A2CYP3A4 | |
| SCHEMBL11240173 | 0.77 | ROCK2 (0.38) | ROCK2CYP19A1PRKCHPRKCEPRKCQ | |
| SCHEMBL11241761 | 0.77 | ALDH1A1 (0.30) | TDP1CYP3A4 | |
| SCHEMBL11378192 | 0.76 | ROCK2 (0.42) | ROCK2CYP19A1PRKCHPRKCEPRKCQ | |
| SCHEMBL6634764 | 0.76 | PRKCH (0.57) | ROCK2PRKCHPRKCEPRKCQPRKCD | |
| SCHEMBL18034738 | 0.74 | ROCK2 (0.41) | ROCK2CYP19A1PRKCHPRKCEPRKCQ | |
| SCHEMBL15771446 | 0.74 | CCNC (0.46) | ROCK2CYP19A1CCNCCDK8SIRT3 | |
| SCHEMBL20632129 | 0.72 | ABL1 (0.43) | MAP4K1ABL1PDE2APDE10ACYP1A2 | |
| SCHEMBL3423341 | 0.72 | CCNC (0.50) | CYP19A1CCNCCDK8SIRT3TDP1 | |
| SCHEMBL16040917 | 0.72 | CCNC (0.45) | ROCK2CYP19A1CCNCCDK8SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |