Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.63 |
| ▸ | PDE5A | O76074 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250277 | 0.92 | APP (0.60) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11243542 | 0.91 | APP (0.56) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11254484 | 0.88 | APP (0.53) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11242191 | 0.83 | APP (0.54) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11249235 | 0.83 | APP (0.56) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11244411 | 0.82 | APP (0.62) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11253738 | 0.81 | APP (0.54) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11255663 | 0.81 | APP (0.51) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL11246642 | 0.81 | APP (0.68) | APPPDE5AMAPK1CYP1A2CYP3A4 | |
| SCHEMBL4904310 | 0.79 | APP (0.70) | APPPDE5ABCHEACHETLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |