Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242191 | 0.93 | APP (0.54) | APPPDE5AALDH1A1KDM4ERAD52 | |
| SCHEMBL11264589 | 0.91 | APP (0.63) | APPPDE5ARAD52POLBCYP1A2 | |
| SCHEMBL11254484 | 0.87 | APP (0.53) | APPPDE5AALDH1A1KDM4ERAD52 | |
| SCHEMBL11250277 | 0.83 | APP (0.60) | APPPDE5AALDH1A1POLBCYP1A2 | |
| SCHEMBL11249235 | 0.82 | APP (0.56) | APPPDE5AALDH1A1KDM4EPOLB | |
| SCHEMBL11255663 | 0.80 | APP (0.51) | APPPDE5AALDH1A1KDM4ERAD52 | |
| SCHEMBL11251275 | 0.80 | GBA1 (0.63) | APPPDE5AALDH1A1KDM4ERAD52 | |
| SCHEMBL11244741 | 0.80 | LDHA (0.59) | APPKDM4EPOLBCYP1A2CYP3A4 | |
| SCHEMBL11244411 | 0.79 | APP (0.62) | APPPDE5AALDH1A1RAD52POLB | |
| SCHEMBL11253738 | 0.78 | APP (0.54) | APPPDE5APOLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |