Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.48 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184433 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1HPGDALDH1A1NPC1 | |
| SCHEMBL24763632 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1HPGDALDH1A1NPC1 | |
| SCHEMBL27871762 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2NPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL10791772 | 0.81 | GAA (0.44) | SMN1; SMN2NPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL1129756 | 0.81 | KMT2A (0.62) | SMN1; SMN2HPGDALDH1A1NPC1L3MBTL1 | |
| SCHEMBL19493715 | 0.81 | RAB9A (0.50) | SMN1; SMN2HPGDALDH1A1RAB9ACYP2C9 | |
| SCHEMBL31372524 | 0.81 | RAB9A (0.50) | SMN1; SMN2HPGDALDH1A1RAB9ACYP2C9 | |
| SCHEMBL2042093 | 0.81 | RAB9A (0.50) | SMN1; SMN2HPGDALDH1A1RAB9ACYP2C9 | |
| SCHEMBL6301896 | 0.81 | HPGD (0.55) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| Water SCHEMBL28259876 | 0.79 | RAB9A (0.49) | SMN1; SMN2HPGDALDH1A1RAB9ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
| US-4316001-A | Anionic polymerization of heterocyclic monomers with alkali metal amide hydroxylated compound initiator | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1982-02-16 | — | — | US | disclosed |
| US-4254247-A | COMPLEXES OF METAL AMIDE AND METAL ALCOHOLATE | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1981-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | KCNJ2, TRPV1, KCNJ1 | SMN1; SMN2 1198/4885NPSR1 672/4885HPGD 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.