Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246333 | 0.85 | PDE3B (0.45) | POLBCYP11B1CYP11B2CYP19A1SMN1; SMN2 | |
| SCHEMBL11227028 | 0.84 | MAPK1 (0.47) | MAPK1POLBCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL11245356 | 0.80 | CYP2A6 (0.44) | MAPK1CYP11B1CYP11B2CYP19A1HTT | |
| SCHEMBL11236490 | 0.78 | NCOA1 (0.39) | MEN1KMT2AHTTSMN1; SMN2NCOA1 | |
| SCHEMBL11238427 | 0.77 | LMNA (0.45) | POLBCYP11B1CYP11B2CYP19A1MEN1 | |
| SCHEMBL11165304 | 0.77 | MKNK1 (0.52) | MAPK1KMT2ALMNA | |
| SCHEMBL11224797 | 0.75 | RAB9A (0.41) | POLBCYP11B1CYP11B2CYP19A1NCOA1 | |
| SCHEMBL11226168 | 0.75 | ALDH1A1 (0.49) | MAPK1CYP11B1CYP11B2KMT2ASMN1; SMN2 | |
| SCHEMBL11237097 | 0.74 | POLB (0.41) | MAPK1POLBCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL11226790 | 0.73 | NPC1 (0.47) | MAPK1CYP11B1CYP11B2CYP19A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |