Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.61 |
| ▸ | PDE2A | O00408 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11246455 | 0.97 | PDE3B (0.58) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL1392639 | 0.84 | ADORA3 (0.56) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL11245286 | 0.81 | CYP1A2 (0.63) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL238785 | 0.81 | MKNK2 (0.47) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL11246270 | 0.77 | CASP1 (0.54) | MAPTCASP1GSK3BGSK3ADYRK1A | |
| SCHEMBL10668965 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE2AMAPTMEN1 | |
| SCHEMBL1754686 | 0.76 | GSK3B (0.49) | MAPTAURKAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7312649 | 0.75 | MAPT (0.51) | PDE3BPDE3APDE2AAURKBINCENP | |
| SCHEMBL2950654 | 0.75 | GSK3B (0.53) | AURKBMAPTALDH1A1CASP1GSK3B | |
| SCHEMBL11231763 | 0.74 | PDE3B (0.46) | PDE3BPDE3APDE2AAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | claimed |
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |