Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392639 | 0.90 | ADORA3 (0.56) | MAPTAURKATHRBCASP1TTK | |
| SCHEMBL28025294 | 0.83 | POLB (0.48) | MAPTAURKATHRBCASP1TTK | |
| SCHEMBL2823296 | 0.83 | IDO1 (0.47) | MAPTAURKATHRBCASP1TTK | |
| SCHEMBL11245286 | 0.77 | CYP1A2 (0.63) | AURKATTKAURKBINCENPPDE3B | |
| SCHEMBL11242864 | 0.75 | PDE3B (0.61) | MAPTAURKATHRBCASP1TTK | |
| SCHEMBL17775678 | 0.74 | RAB9A (0.78) | MAPTADORA3POLBRAB9ATP53 | |
| SCHEMBL17279909 | 0.74 | POLB (0.71) | MAPTADORA3POLBRAB9ATP53 | |
| SCHEMBL11293296 | 0.72 | PIN1 (0.54) | MAPTPDE3BPDE3APDE2APRMT5 | |
| Hydrochloric Acid SCHEMBL11246455 | 0.72 | PDE3B (0.58) | MAPTAURKATHRBCASP1TTK | |
| SCHEMBL1754735 | 0.72 | POLB (0.57) | MAPTAURKBADORA3POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |