Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237972 | 0.81 | PDE3B (0.60) | LMNAHPGDTSHRBLMKDM4E | |
| SCHEMBL11233155 | 0.76 | CYP11B1 (0.46) | MAPTHPGDKDM4EPDE3BPDE3A | |
| SCHEMBL11241138 | 0.76 | GRIA1 (0.42) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL215905 | 0.73 | KDM4E (0.52) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL10910836 | 0.71 | PDE3A (0.67) | LMNAHPGDTSHRBLMCYP3A4 | |
| SCHEMBL28457504 | 0.70 | KDM4E (0.49) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11800255 | 0.70 | ALDH1A1 (0.43) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL9332963 | 0.69 | KDM4E (0.47) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11229699 | 0.68 | PDE3B (0.43) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL9846127 | 0.68 | MAPT (0.47) | GRIA1GRIA2GRIA3GRIA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |