Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11163903 | 0.82 | HTR2A (0.36) | CYP1A2HTR2AHRH1LMNAKMT2A | |
| SCHEMBL11161993 | 0.78 | NOS2 (0.39) | CYP2D6SLC6A2HTR2AHRH1SLC6A4 | |
| SCHEMBL11172935 | 0.78 | IRAK4 (0.51) | KDM4ECYP3A4TSHROPRK1HTR2B | |
| SCHEMBL6693445 | 0.78 | ALOX15 (0.46) | ALOX15CYP1A2KDM4ESCN4ACYP2D6 | |
| SCHEMBL4071169 | 0.75 | ALOX15 (0.44) | ALOX15CYP1A2KDM4ESCN4ACYP2D6 | |
| SCHEMBL11242894 | 0.70 | ALOX15 (0.57) | ALOX15CYP1A2KDM4ESCN4ACYP2D6 | |
| SCHEMBL5960259 | 0.70 | ALOX15 (0.49) | ALOX15CYP1A2KDM4ESCN4ACYP2D6 | |
| SCHEMBL27684350 | 0.68 | SCN4A (0.48) | ALOX15CYP1A2KDM4ESCN4ACYP2D6 | |
| SCHEMBL11244735 | 0.68 | TSHR (0.36) | ALOX15CYP1A2SCN4ACYP2D6SLC6A2 | |
| SCHEMBL10926266 | 0.68 | HTR1B (0.56) | ALOX15KDM4ESCN4ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4318921-A | HYPOTENSIVE AGENTS; ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-03-09 | — | — | US | disclosed |