Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 9/20 | 0.58 |
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11242521 | 0.87 | TBXAS1 (0.71) | TBXAS1BRD4L3MBTL1ALDH1A1PKM | |
| SCHEMBL11233639 | 0.83 | TBXAS1 (0.57) | TBXAS1BRD4L3MBTL1ALDH1A1PKM | |
| SCHEMBL11242787 | 0.81 | TBXAS1 (0.50) | TBXAS1BRD4CYP11B1CYP11B2POLB | |
| SCHEMBL11407205 | 0.78 | CYP11B1 (0.54) | TBXAS1ALDH1A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL11405750 | 0.77 | CYP19A1 (0.48) | TBXAS1ALDH1A1CYP11B1CYP11B2LMNA | |
| SCHEMBL11228730 | 0.77 | CYP19A1 (0.51) | TBXAS1BRD4CYP11B1CYP11B2LMNA | |
| SCHEMBL11414669 | 0.76 | FNTA (0.57) | TBXAS1CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL11412353 | 0.76 | ADRB2 (0.49) | TBXAS1BRD4L3MBTL1ALDH1A1CYP11B1 | |
| SCHEMBL11406871 | 0.76 | ALDH1A1 (0.47) | TBXAS1BRD4L3MBTL1ALDH1A1CYP11B1 | |
| SCHEMBL11416852 | 0.76 | CYP19A1 (0.49) | TBXAS1BRD4L3MBTL1ALDH1A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339583-A | (Imidazolylmethyl)pyridine compounds as thromboxane synthetase inhibitors | PFIZER INC. (US) | 1982-07-13 | — | — | US | disclosed |
| EP-0029742-A1 | Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof | Pfizer Limited (GB) | 1981-06-03 | — | — | EP | disclosed |