Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11253254 | 0.88 | SIGMAR1 (0.43) | KCNH2 | |
| SCHEMBL11255519 | 0.87 | SIGMAR1 (0.39) | KDM4EKIF11KCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11261152 | 0.86 | CHRM3 (0.36) | HTR2AHRH1KCNH2CHRM2CHRM4 | |
| SCHEMBL11335854 | 0.84 | UTS2R (0.45) | HTR2AHRH1UTS2R | |
| Hydrochloric Acid SCHEMBL11277460 | 0.83 | UTS2R (0.44) | HTR2AHRH1UTS2R | |
| Hydrochloric Acid SCHEMBL11248207 | 0.81 | HTR2A (0.49) | HTR2AHRH1KDM4EHTR7UTS2R | |
| SCHEMBL11333840 | 0.79 | KDM4E (0.45) | KDM4EKCNH2ALDH1A1CHRM3ADRB2 | |
| SCHEMBL11253048 | 0.78 | ADRB2 (0.41) | KCNH2ALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL11343391 | 0.77 | RIPK1 (0.38) | KIF11KCNH2CHRM1CHRM3ADRB2 | |
| Hydrochloric Acid SCHEMBL11256182 | 0.77 | ADRB2 (0.40) | KCNH2ALDH1A1CHRM3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277471-A | 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | claimed |
| EP-0015776-B1 | 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME | ELI LILLY AND COMPANY (US) | 1982-06-30 | — | — | EP | disclosed |
| US-4277471-A | 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0015776-A1 | 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same | ELI LILLY AND COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |