Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243561 | 0.82 | SIGMAR1 (0.33) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL11246415 | 0.81 | MEN1 (0.30) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL11246407 | 0.81 | MEN1 (0.30) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL11233175 | 0.81 | SIGMAR1 (0.33) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL9698946 | 0.80 | CHRM2 (0.37) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL11238695 | 0.78 | CYP1A2 (0.31) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL11238705 | 0.78 | CYP1A2 (0.31) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL11232809 | 0.77 | P2RX7 (0.35) | KMT2ABRD4P2RX7 | |
| Fumaric Acid SCHEMBL11244743 | 0.75 | PLA2G10 (0.34) | SMN1; SMN2MEN1KMT2ALMNA | |
| Fumaric Acid SCHEMBL11244739 | 0.75 | PLA2G10 (0.34) | SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4327098-A | Pharmaceutical compositions useful in the treatment of cardiovascular hypertension and containing 4-substituted-2-iminoimadazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4327108-A | Methods useful in the treatment of cardiac arrhythmia using 4-substituted-2-iminoimidazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4327107-A | Method useful in the treatment of sugar cataracts using 4-substituted-2-iminoimidazolidine compounds | A. H. ROBINS COMPANY, INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4288447-A | Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions | A. H. ROBINS COMPANY, INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4288591-A | ANTIINFLAMMATORY, HYPOTENSIVE, HYPOGLYCEMIC | A. H. ROBINS COMPANY, INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4247705-A | HYPOTENSIVE, HYPOGLYCEMIC, ANTIINFLAMMATORY | A. H. ROBINS COMPANY, INC. (US) | 1981-01-27 | — | — | US | disclosed |