SCHEMBL11243922

SCHEMBL11243922

Oc1ccc(/C=N/n2cnnc2S)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AMY1A P0DUB6 3/20 0.56
MAPT P10636 7/20 0.41
SMN1; SMN2 Q16637 5/20 0.41
NPC1 O15118 5/20 0.41
ALDH1A1 P00352 4/20 0.41
RAB9A P51151 4/20 0.41
PKM P14618 3/20 0.41
GAA P10253 3/20 0.41
KDM4E B2RXH2 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ATM Q13315 1/20 0.41
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
TP53 P04637 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
MAPK1 P28482 3/20 0.39
MCL1 Q07820 2/20 0.39
GFER P55789 1/20 0.39
USP2 O75604 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11243927 1.00 AMY1A (0.56) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL28867947 0.78 AMY1A (0.53) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL24727973 0.72 AMY1A (1.00) AMY1AMAPTSMN1; SMN2ALDH1A1PKM
SCHEMBL28558439 0.67 ALDH1A1 (0.73) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL31499008 0.67 ALDH1A1 (0.73) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL9928639 0.61 ALDH1A1 (0.48) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL9621788 0.61 ALDH1A1 (1.00) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL12557406 0.61 ALDH1A1 (1.00) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL2164065 0.59 ALDH1A1 (0.67) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL91114 0.59 ALDH1A1 (0.67) AMY1AMAPTSMN1; SMN2NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4310621-A DEVELOPMENT INHIBITORS AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) 1982-01-12 US disclosed