Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MGMT | P16455 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235025 | 0.85 | RAB9A (0.40) | NCOA1NCOA3POLBGSK3BRAB9A | |
| SCHEMBL11238568 | 0.82 | POLB (0.41) | NCOA1NCOA3POLBGSK3BRAB9A | |
| SCHEMBL11234862 | 0.81 | POLB (0.41) | NCOA1NCOA3POLBGSK3BRAB9A | |
| SCHEMBL11237967 | 0.81 | POLB (0.39) | POLBRAB9ANPC1DHFRGAA | |
| SCHEMBL3789859 | 0.77 | RAB9A (0.40) | POLBRAB9ANPC1DHFRCDC7 | |
| SCHEMBL3792526 | 0.76 | RAB9A (0.45) | NCOA1NCOA3POLBRAB9ANPC1 | |
| SCHEMBL11236617 | 0.75 | RAB9A (0.38) | POLBRAB9ANPC1DHFRGAA | |
| SCHEMBL11235965 | 0.72 | PDE3B (0.43) | POLBGSK3BRAB9ACDC7 | |
| SCHEMBL4060442 | 0.72 | ADK (0.42) | RAB9ANPC1DHFRGAAMAPT | |
| SCHEMBL3788901 | 0.72 | ADORA2B (0.37) | RAB9ANPC1DHFRCDC7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |