SCHEMBL11244138

SCHEMBL11244138

Cc1cc(NC(=O)NC(=O)c2ccccc2Cl)ccc1OCc1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.61
EPHX2 P34913 5/20 0.52
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
POLB P06746 1/20 0.51
PKM P14618 1/20 0.51
PYGL P06737 3/20 0.50
PNLIP P16233 2/20 0.49
PCTP Q9UKL6 1/20 0.48
PPARA Q07869 1/20 0.48
ALOX5 P09917 4/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C19 P33261 1/20 0.47
ATM Q13315 1/20 0.47
PLCG2 P16885 1/20 0.46
MRGPRX4 Q96LA9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11251747 0.94 GCGR (0.55) GCGREPHX2NPC1RAB9APOLB
SCHEMBL11233013 0.93 PNLIP (0.53) GCGREPHX2NPC1RAB9APOLB
SCHEMBL11237411 0.91 GCGR (0.71) GCGRNPC1RAB9APOLBPKM
SCHEMBL11236840 0.89 LRRK2 (0.50) GCGREPHX2NPC1RAB9APOLB
SCHEMBL11242062 0.88 TDP1 (0.67) GCGREPHX2NPC1RAB9APOLB
SCHEMBL11240053 0.88 PYGL (0.53) GCGRNPC1RAB9APOLBPKM
SCHEMBL11383033 0.87 MEN1 (0.53) GCGRNPC1RAB9APOLBPKM
SCHEMBL11388824 0.86 GCGR (0.62) GCGRNPC1RAB9APOLBPKM
SCHEMBL11240737 0.85 S1PR1 (0.59) GCGRNPC1RAB9APOLBPKM
SCHEMBL11245808 0.84 GCGR (0.64) GCGRNPC1RAB9APOLBPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4350706-A MITICIDES, LARVICIDES DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1982-09-21 US disclosed