Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181741 | 0.83 | HPGD (0.41) | HPGDL3MBTL1KDM4ETSHRALDH1A1 | |
| SCHEMBL3370115 | 0.74 | HPGD (0.49) | HPGDL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30363500 | 0.74 | HPGD (0.49) | HPGDL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3370114 | 0.74 | HPGD (0.49) | HPGDL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10041963 | 0.74 | HPGD (0.49) | HPGDL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14461584 | 0.73 | IDO1 (0.59) | IDO1ACHE | |
| SCHEMBL6328560 | 0.71 | HPGD (0.44) | HPGDL3MBTL1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL6328564 | 0.71 | HPGD (0.44) | HPGDL3MBTL1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL8736255 | 0.71 | HPGD (0.44) | HPGDL3MBTL1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL5263072 | 0.70 | HRH1 (0.39) | HPGDL3MBTL1SMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011747-B1 | AMINOPROPANOL DERIVATIVES OF 6-HYDROXY-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1982-05-19 | — | — | EP | disclosed |