SCHEMBL11244641

SCHEMBL11244641

Cc1[nH]c2ccccc2c1C1(c2ccc(N(C)C)cc2N(C)C)OC(=O)c2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
TDP1 Q9NUW8 3/20 0.45
CYP3A4 P08684 2/20 0.45
HPGD P15428 2/20 0.45
HIF1A Q16665 1/20 0.45
HSD17B10 Q99714 1/20 0.45
LMNA P02545 5/20 0.40
NPSR1 Q6W5P4 2/20 0.40
MEN1 O00255 5/20 0.39
KMT2A Q03164 5/20 0.39
MAPT P10636 7/20 0.39
HTT P42858 3/20 0.39
USP2 O75604 2/20 0.39
FTO Q9C0B1 2/20 0.39
ALOX12 P18054 2/20 0.39
POLB P06746 2/20 0.39
GPR55 Q9Y2T6 1/20 0.39
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11251422 0.91 LMNA (0.43) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL5147481 0.91 MAPT (0.47) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL10528872 0.89 LMNA (0.42) ALDH1A1TDP1CYP3A4HPGDHSD17B10
SCHEMBL31715256 0.89 LMNA (0.42) ALDH1A1TDP1CYP3A4HPGDHSD17B10
SCHEMBL11259480 0.89 ALDH1A1 (0.40) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL11264471 0.88 HPGD (0.43) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL11257945 0.86 ALDH1A1 (0.39) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL337223 0.85 ALDH1A1 (0.51) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL29383061 0.85 ALDH1A1 (0.51) ALDH1A1TDP1CYP3A4HPGDHIF1A
SCHEMBL13382768 0.84 MAPT (0.41) ALDH1A1TDP1CYP3A4HPGDHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4351768-A CARBONLESS, DUPLICATION, INDOLE DYES STERLING DRUG INC. (US) 1982-09-28 US disclosed
US-4322352-A Indolyl phthalide compounds STERLING DRUG INC. (US) 1982-03-30 US disclosed
US-4307018-A CHROMOGENS FOR COPYING SYSTEMS STERLING DRUG INC. (US) 1981-12-22 US disclosed
US-4251446-A COLOR PRECURSORS STERLING DRUG INC. (US) 1981-02-17 US disclosed
US-4189171-A PRESSURE SENSITIVE, THERMAL AND HECTOGRAPHIC SYSTEMS STERLING DRUG INC. (US) 1980-02-19 US disclosed