Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663306 | 0.88 | MAPT (0.50) | SMN1; SMN2NPC1KMT2APOLBCDC25B | |
| SCHEMBL11427275 | 0.85 | MAPT (0.48) | SMN1; SMN2NPC1CDC25BMAPTRAB9A | |
| SCHEMBL11045406 | 0.81 | KMT2A (0.48) | SMN1; SMN2NPC1KMT2APOLBCDC25B | |
| SCHEMBL10567455 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1KMT2APOLBCDC25B | |
| SCHEMBL11247014 | 0.79 | CES2 (0.47) | SMN1; SMN2KMT2APOLBMAPTRAB9A | |
| SCHEMBL613121 | 0.79 | MAPT (0.66) | SMN1; SMN2KMT2ACDC25BMAPTRAB9A | |
| SCHEMBL11049604 | 0.78 | MAPT (0.49) | SMN1; SMN2NPC1KMT2APOLBCDC25B | |
| SCHEMBL10661825 | 0.78 | MAPT (0.52) | SMN1; SMN2NPC1KMT2APOLBCDC25B | |
| SCHEMBL15100552 | 0.78 | NPC1 (0.46) | SMN1; SMN2NPC1KMT2APOLBMAPT | |
| SCHEMBL4935615 | 0.77 | NPC1 (0.60) | SMN1; SMN2NPC1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337261-A | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0045078-A1 | (1,2-Benzisoxazol)phenoxyacetic acids and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-03 | — | — | EP | disclosed |