Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132989 | 0.83 | NPC1 (0.42) | MEN1KMT2AHSD17B10GAAALDH1A1 | |
| SCHEMBL30293901 | 0.79 | CES2 (0.71) | CES2CES1MEN1KMT2AGAA | |
| SCHEMBL11244683 | 0.79 | SMN1; SMN2 (0.51) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL250099 | 0.79 | CES2 (0.71) | CES2CES1MEN1KMT2AGAA | |
| SCHEMBL30070831 | 0.78 | CSNK2A1 (0.53) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL21486405 | 0.78 | CSNK2A1 (0.53) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL31220395 | 0.77 | CES2 (0.58) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL9390040 | 0.77 | CES2 (0.58) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL11241888 | 0.77 | MGLL (0.39) | CES2CES1MEN1KMT2AHSD17B10 | |
| SCHEMBL31574193 | 0.77 | CES2 (0.68) | CES2CES1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337261-A | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0045078-A1 | (1,2-Benzisoxazol)phenoxyacetic acids and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-03 | — | — | EP | disclosed |