SCHEMBL11244841

SCHEMBL11244841

O=C(NC(=O)c1c(Cl)cccc1Cl)Nc1ccc(O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.51
MAOB P27338 1/20 0.51
TYK2 P29597 2/20 0.51
JAK2 O60674 1/20 0.51
CYP3A4 P08684 1/20 0.51
JAK1 P23458 1/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
ALDH1A1 P00352 2/20 0.51
TAS1R3 Q7RTX0 1/20 0.51
TAS1R1 Q7RTX1 1/20 0.51
TAS1R2 Q8TE23 1/20 0.51
GAA P10253 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
KMT2A Q03164 3/20 0.50
PYGL P06737 1/20 0.48
PPIA P62937 1/20 0.48
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dichlorbenzuron SCHEMBL3663126 0.89 CNR1 (0.54) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL7605864 0.87 KMT2A (0.61) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL9352624 0.86 NPC1 (0.50) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL7603457 0.86 KMT2A (0.59) MAOAMAOBTYK2JAK2CYP3A4
SCHEMBL7604279 0.86 TYK2 (0.50) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL7600272 0.86 GAA (0.55) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL7606210 0.84 SMO (0.57) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL9348787 0.83 RAB9A (0.58) TYK2JAK2CYP3A4JAK1NPC1
SCHEMBL7603611 0.83 RAB9A (0.50) TYK2JAK2CYP3A4JAK1NPC1
Urea SCHEMBL10392049 0.83 KMT2A (0.56) TYK2JAK2CYP3A4JAK1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4350706-A MITICIDES, LARVICIDES DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1982-09-21 US disclosed